8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity
نویسندگان
چکیده
A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and tert-butyltetrazole moieties differ in chain length, basicity substitution. Compounds were tested for their antiplasmodial activity against Plasmodium falciparum NF54 as well cytotoxicity L-6-cells. The strongly influenced by linker most active showed good promising selectivity.
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ژورنال
عنوان ژورنال: Molecules
سال: 2021
ISSN: ['1420-3049']
DOI: https://doi.org/10.3390/molecules26185530